Penn State University
- College of Medicine at the Milton S. Hershey Medical Center
- Date Announced:
- Date Closing:
- open until filled
- Job Number:
- Work Unit:
- Penn State College of Medicine
Epigenetic regulation in normal and malignant hematopoiesis: The department of Pediatric Hematology/Oncology is currently accepting applications for entry- and senior-level postdoctoral/Scientist positions. The lab focuses on delineating the epigenetic pathways that regulate normal hematopoiesis and to further determine how regulatory networks are perturbed in anemia, leukemia, and solid tumors. Our current research focuses are: Investigating the underlying molecular mechanisms that connect chromatin loops with transcription activation of the TAL1/SCL oncogene. We are also studying the role of CTCF-mediated 3D genome organization in enhancer/promoter interactions, oncogene activation, and chromosome translocation during T-cell leukemogenesis. Dissecting chromatin insulator structure and studying the mechanism by which barrier insulator establishes and maintains active chromatin domains and promoter accessibility to control the hematopoietic transcription program and lineage differentiation. Delineating the role of long noncoding RNAs in hematopoiesis and leukemogenesis. We utilize a variety of approaches including biochemical, proteomic, genomic, genome editing, mouse modeling, human primary cell system, and ESC system to study these questions. Candidates should have obtained a PhD or an MD/PhD degree in the fields of Molecular Biology, Cellular Biology, Biochemistry, Development, or Genetics. The candidate should have evidence of prior productive scientific work in the form of publications in peer-reviewed journals. Prior experience in the study of gene regulation, hematopoiesis, bioinformatics analysis, and/or use of mouse models is preferred. Interested candidates should upload their Curriculum Vitae and a cover letter describing their background and research interests.
These salary bands have been established to provide salary guidelines for staff positions.